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Where do we go from here, and what can I do to recognise pain in my research animals?
Our ability to assess pain after surgery in most species is still very limited, making it difficult to ensure we are managing pain effectively with analgesics or other treatments. This situation will improve as pain assessment schemes are developed and validated, but in the meantime, the following approach can be suggested:
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Carprofen
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Meloxicam
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Buprenorphine
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Morphine
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Mouse
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10 mg/kg s.c.
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5 mg/kg s.c.
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0.1 mg/kg s.c.
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2 - 5 mg/kg s.c.
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Rat
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5 mg/kg s.c.
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1 - 2 mg/kg s.c. or 4 mg/kg per os
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0.01 - 0.05 mg/kg s.c.
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2 - 5 mg/kg s.c.
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Rabbit
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4 mg/kg s.c.
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0.2 – 0.4 mg/kg s.c., 0.2 - 0.6mg/kg per os
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0.01 - 0.05 mg/kg s.c
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2 - 5 mg/kg s.c. or i.m
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Guinea Pig
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2 - 5 mg/kg s.c.
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?
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0.05 mg/kg s.c.
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2 - 5 mg/kg s.c. or i.m
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Dog
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4 mg/kg i.v., s.c. or per os
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0.2 mg/kg s.c. or 0.1 mg/kg per os
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0.01 - 0.02 mg/kg s.c., i.m. or i.v.
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0.3 - 1.0 mg/kg s.c. or i.m.
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Cat
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2 - 4 mg/kg i.v. or s.c.
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0.3 mg/kg s.c. or 0.1 mg/kg per os
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0.01 - 0.02 mg/kg s.c., i.m. or i.v.
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0.1 - 0.2 mg/kg s.c.
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Rhesus Macaque
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4 mg/kg s.c.
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0.1 mg/kg s/c or per os
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0.005 - 0.01 mg/kg s.c., i.m. or i.v.
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1 - 2 mg/kg s.c. or i.m.
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Sheep
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1.5 - 2 mg/kg s.c. or i.v.
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?
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0.005 - 0.01 mg/kg i.m. or i.v.
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0.2 - 0.5 mg/kg i.m.
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